Scientist

Principal Scientist

Roche is seeking a highly motivated Principal Scientist to support the development of advanced molecular diagnostics technologies. This role involves the entire product development lifecycle, from early-stage research to on-market support, focusing on the synthesis, purification, and characterization of complex nucleotides, oligonucleotides, and small molecule reagents.

Responsibilities

• Synthesize and characterize complex nucleotides, phosphoramidites, and oligonucleotides while driving process optimization for scale-up.
• Support and utilize analytical methods for characterizing reagents and assay performance.
• Design and execute advanced troubleshooting experiments and develop assays to ensure robust design.
• Manage knowledge handoffs and transfer documentation from research to manufacturing teams.
• Act as a subject matter expert to provide technical depth across R&D and operations.

Requirements

• Ph.D. in Chemistry, Biochemistry, or related field with 2+ years of industry experience, or a Master’s Degree with 5+ years of experience.
• Demonstrated expertise in UPLC/HPLC, ion pair/exchange chromatography, mass spectrometry, and spectroscopy.
• In-depth knowledge of synthetic methods for oligonucleotides, DNA/RNA modifications, and PCR methodologies.
• Proven skills in experimental design and optimizing analytical assays.
• Strong technical writing, problem-solving, and interpersonal skills with the ability to influence cross-functional teams.